The second Crossroads Concert, a day-long concert featuring legendary music and collaborations, was filmed on July 28, 2007 to benefit the Crossroads Centre in Antigua. The festival featured the music of Clapton, along with that of many other musicians, including Jeff Beck, Sheryl Crow, Vince Gill, Buddy Guy, B.B. King, Los Lobos, John Mayer, Willie Nelson, Robert Randolph, Robbie Robertson and more. Rhino's royalties from the sale of this DVD will benefit Crossroads Centre. Also includes behind-the-scenes footage.

In 2004 the Cotton Bowl in Dallas, Texas, played host to the first Crossroads Guitar Festival--a musical event curated by Eric Clapton. The 2007 incarnation of the event followed a similar pattern to the first show, and features stars such as Jeff Beck, Sheryl Crow, Willie Nelson, and Buddy Guy. Many of the musicians perform guest slots with other acts on the bill, making this a truly special occasion, and Clapton also uses the event to pay a moving tribute to the recently deceased Beatle George Harrison. All the money generated by the concert goes to aid the Crossroads Center, which is a nonprofit addiction treatment facility in Antigua.